Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Susanne Walz, Francesca Lorenzin, Jennifer Morton, Katrin E. Wiese, Björn von Eyss, Steffi Herold, Lukas Rycak, Hélène Dumay-Odelot, Saadia Karim, Marek Bartkuhn, Frederik Roels, Torsten Wüstefeld, Matthias Fischer, Martin Teichmann, Lars Zender, Chia-Lin Wei, Owen Sansom, Elmar Wolf () and Martin Eilers ()
Additional contact information
Susanne Walz: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Francesca Lorenzin: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Jennifer Morton: CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
Katrin E. Wiese: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Björn von Eyss: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Steffi Herold: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Lukas Rycak: Institute for Molecular Biology and Tumor Research (IMT), Emil-Mannkopff-Str.2, 35033 Marburg, Germany
Hélène Dumay-Odelot: University of Bordeaux, IECB, ARNA laboratory, Equipe Labellisée Contre le Cancer, 33600 Pessac, France
Saadia Karim: CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
Marek Bartkuhn: Institute for Genetics, Justus-Liebig-University, Heinrich-Buff-Ring 58, 35390 Giessen, Germany
Frederik Roels: University Children’s Hospital of Cologne, and Cologne Center for Molecular Medicine (CMMC), University of Cologne, Kerpener Str. 62, 50924 Cologne, Germany
Torsten Wüstefeld: University Hospital Tübingen, Otfried-Mueller-Strasse 10, 72076 Tübingen, Germany
Matthias Fischer: University Children’s Hospital of Cologne, and Cologne Center for Molecular Medicine (CMMC), University of Cologne, Kerpener Str. 62, 50924 Cologne, Germany
Martin Teichmann: University of Bordeaux, IECB, ARNA laboratory, Equipe Labellisée Contre le Cancer, 33600 Pessac, France
Lars Zender: University Hospital Tübingen, Otfried-Mueller-Strasse 10, 72076 Tübingen, Germany
Chia-Lin Wei: DOE Joint Genome Institute, 2800 Mitchell Drive
Owen Sansom: CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
Elmar Wolf: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Martin Eilers: Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

Nature, 2014, vol. 511, issue 7510, 483-487

Abstract: Inducing changes in the levels of the MYC oncoprotein is shown to activate and repress specific sets of target genes that are characteristic of tumour cells, providing an insight into the mechanism by which MYC can stimulate tumorigenesis in contrast to its physiological role.

Date: 2014
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DOI: 10.1038/nature13473

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