Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

Arianna Sabò, Theresia R. Kress, Mattia Pelizzola, Stefano de Pretis, Marcin M. Gorski, Alessandra Tesi, Marco J. Morelli, Pranami Bora, Mirko Doni, Alessandro Verrecchia, Claudia Tonelli, Giovanni Fagà, Valerio Bianchi, Alberto Ronchi, Diana Low, Heiko Müller, Ernesto Guccione, Stefano Campaner and Bruno Amati ()
Additional contact information
Arianna Sabò: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Theresia R. Kress: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Mattia Pelizzola: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Stefano de Pretis: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Marcin M. Gorski: European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy
Alessandra Tesi: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Marco J. Morelli: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Pranami Bora: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Mirko Doni: European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy
Alessandro Verrecchia: European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy
Claudia Tonelli: European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy
Giovanni Fagà: European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy
Valerio Bianchi: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Alberto Ronchi: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Diana Low: Institute of Molecular and Cell Biology, Singapore 138673, Singapore
Heiko Müller: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Ernesto Guccione: Institute of Molecular and Cell Biology, Singapore 138673, Singapore
Stefano Campaner: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
Bruno Amati: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy

Nature, 2014, vol. 511, issue 7510, 488-492

Abstract: Global transcriptional and epigenomic analyses in diverse cell types reveal that the primary action of Myc is to up- and downregulate transcription of distinct groups of genes, rather than to amplify transcription of all active genes; general RNA amplification, when observed, is better explained as an indirect consequence of Myc’s action on cellular physiology.

Date: 2014
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DOI: 10.1038/nature13537

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