Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

Netanya G. Sandler, Steven E. Bosinger, Jacob D. Estes, Richard T. R. Zhu, Gregory K. Tharp, Eli Boritz, Doron Levin, Sathi Wijeyesinghe, Krystelle Nganou Makamdop, Gregory Q. del Prete, Brenna J. Hill, J. Katherina Timmer, Emma Reiss, Ganit Yarden, Samuel Darko, Eduardo Contijoch, John Paul Todd, Guido Silvestri, Martha Nason, Robert B. Norgren, Brandon F. Keele, Srinivas Rao, Jerome A. Langer, Jeffrey D. Lifson, Gideon Schreiber and Daniel C. Douek ()
Additional contact information
Netanya G. Sandler: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Steven E. Bosinger: Emory Vaccine Center, Yerkes National Primate Research Center
Jacob D. Estes: AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA
Richard T. R. Zhu: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Gregory K. Tharp: Emory Vaccine Center, Yerkes National Primate Research Center
Eli Boritz: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Doron Levin: Weizmann Institute of Science, Rehovot 76100, Israel
Sathi Wijeyesinghe: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Krystelle Nganou Makamdop: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Gregory Q. del Prete: AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA
Brenna J. Hill: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
J. Katherina Timmer: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Emma Reiss: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Ganit Yarden: Weizmann Institute of Science, Rehovot 76100, Israel
Samuel Darko: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Eduardo Contijoch: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
John Paul Todd: Laboratory of Animal Medicine, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Guido Silvestri: Emory Vaccine Center, Yerkes National Primate Research Center
Martha Nason: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Robert B. Norgren: Cell Biology and Anatomy, University of Nebraska Medical Center
Brandon F. Keele: AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA
Srinivas Rao: Laboratory of Animal Medicine, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Jerome A. Langer: Rutgers - Robert Wood Johnson Medical School
Jeffrey D. Lifson: AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA
Gideon Schreiber: Weizmann Institute of Science, Rehovot 76100, Israel
Daniel C. Douek: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health

Nature, 2014, vol. 511, issue 7511, 601-605

Abstract: The timing of type I interferon signalling determines the disease course of SIV infection.

Date: 2014
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DOI: 10.1038/nature13554

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