PTEX is an essential nexus for protein export in malaria parasites

Brendan Elsworth, Kathryn Matthews, Catherine Q. Nie, Ming Kalanon, Sarah C. Charnaud, Paul R. Sanders, Scott A. Chisholm, Natalie A. Counihan, Philip J. Shaw, Paco Pino, Jo-Anne Chan, Mauro F. Azevedo, Stephen J. Rogerson, James G. Beeson, Brendan S. Crabb (), Paul R. Gilson () and Tania F. de Koning-Ward ()
Additional contact information
Brendan Elsworth: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Kathryn Matthews: Deakin University, Waurn Ponds, 3216, Australia
Catherine Q. Nie: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Ming Kalanon: Deakin University, Waurn Ponds, 3216, Australia
Sarah C. Charnaud: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Paul R. Sanders: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Scott A. Chisholm: Deakin University, Waurn Ponds, 3216, Australia
Natalie A. Counihan: Deakin University, Waurn Ponds, 3216, Australia
Philip J. Shaw: National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathum Thani 12120, Thailand
Paco Pino: The University of Geneva, 1211 Geneva 4, Switzerland
Jo-Anne Chan: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Mauro F. Azevedo: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Stephen J. Rogerson: The University of Melbourne, Parkville, Victoria, 3010 Australia
James G. Beeson: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Brendan S. Crabb: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Paul R. Gilson: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia
Tania F. de Koning-Ward: Deakin University, Waurn Ponds, 3216, Australia

Nature, 2014, vol. 511, issue 7511, 587-591

Abstract: This paper demonstrates that a protein complex known as PTEX translocates all malaria parasite proteins destined for export into the cytosol of their host red blood cell.

Date: 2014
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DOI: 10.1038/nature13555

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