DNA methylation dynamics of the human preimplantation embryo

Zachary D. Smith, Michelle M. Chan, Kathryn C. Humm, Rahul Karnik, Shila Mekhoubad, Aviv Regev, Kevin Eggan () and Alexander Meissner ()
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Zachary D. Smith: Broad Institute of MIT and Harvard
Michelle M. Chan: Broad Institute of MIT and Harvard
Kathryn C. Humm: Harvard University
Rahul Karnik: Broad Institute of MIT and Harvard
Shila Mekhoubad: Harvard University
Aviv Regev: Broad Institute of MIT and Harvard
Kevin Eggan: Broad Institute of MIT and Harvard
Alexander Meissner: Broad Institute of MIT and Harvard

Nature, 2014, vol. 511, issue 7511, 611-615

Abstract: Genome-scale DNA methylation maps over early human embryogenesis and embryonic stem cell derivation provide insights into shared and unique modes of regulation when compared to the mouse model, including relationships to gene expression, transposable element activity, and maternal-specific methylation.

Date: 2014
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DOI: 10.1038/nature13581

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