Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells

Zohar Shipony, Zohar Mukamel, Netta Mendelson Cohen, Gilad Landan, Elad Chomsky, Shlomit Reich Zeliger, Yael Chagit Fried, Elena Ainbinder, Nir Friedman and Amos Tanay ()
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Zohar Shipony: Weizmann Institute of Science, Rehovot 76100, Israel
Zohar Mukamel: Weizmann Institute of Science, Rehovot 76100, Israel
Netta Mendelson Cohen: Weizmann Institute of Science, Rehovot 76100, Israel
Gilad Landan: Weizmann Institute of Science, Rehovot 76100, Israel
Elad Chomsky: Weizmann Institute of Science, Rehovot 76100, Israel
Shlomit Reich Zeliger: Weizmann Institute of Science, Rehovot 76100, Israel
Yael Chagit Fried: Weizmann Institute of Science, Rehovot 76100, Israel
Elena Ainbinder: Weizmann Institute of Science, Rehovot 76100, Israel
Nir Friedman: Weizmann Institute of Science, Rehovot 76100, Israel
Amos Tanay: Weizmann Institute of Science, Rehovot 76100, Israel

Nature, 2014, vol. 513, issue 7516, 115-119

Abstract: Using a new method to estimate DNA methylation turnover rate, embryonic stem cells are shown to lack clonal transmission of methylation but still maintain a stable epigenetic state, whereas somatic cells transmit methylation clonally but lose epigenetic state coherence owing to the persistence of accumulated methylation errors.

Date: 2014
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DOI: 10.1038/nature13458

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