High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

Ankita Srivastava (), Jason Yano, Yoshihiko Hirozane, Georgia Kefala, Franz Gruswitz, Gyorgy Snell, Weston Lane, Anthony Ivetac, Kathleen Aertgeerts, Jasmine Nguyen, Andy Jennings and Kengo Okada
Additional contact information
Ankita Srivastava: Takeda California, 10410 Science Center Drive
Jason Yano: Takeda California, 10410 Science Center Drive
Yoshihiko Hirozane: Biomolecular Research Laboratories, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan
Georgia Kefala: Takeda California, 10410 Science Center Drive
Franz Gruswitz: Takeda California, 10410 Science Center Drive
Gyorgy Snell: Takeda California, 10410 Science Center Drive
Weston Lane: Takeda California, 10410 Science Center Drive
Anthony Ivetac: Takeda California, 10410 Science Center Drive
Kathleen Aertgeerts: Takeda California, 10410 Science Center Drive
Jasmine Nguyen: Takeda California, 10410 Science Center Drive
Andy Jennings: Takeda California, 10410 Science Center Drive
Kengo Okada: Biomolecular Research Laboratories, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

Nature, 2014, vol. 513, issue 7516, 124-127

Abstract: The X-ray crystal structure of human GPR40 receptor in the presence of TAK-875, an orally available, potent and selective human GPR40 agonist.

Date: 2014
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DOI: 10.1038/nature13494

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