Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

Serkan Kir, James P. White, Sandra Kleiner, Lawrence Kazak, Paul Cohen, Vickie E. Baracos and Bruce M. Spiegelman ()
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Serkan Kir: Dana-Farber Cancer Institute, Harvard Medical School
James P. White: Dana-Farber Cancer Institute, Harvard Medical School
Sandra Kleiner: Dana-Farber Cancer Institute, Harvard Medical School
Lawrence Kazak: Dana-Farber Cancer Institute, Harvard Medical School
Paul Cohen: Dana-Farber Cancer Institute, Harvard Medical School
Vickie E. Baracos: University of Alberta, Edmonton T6G 1Z2, Canada
Bruce M. Spiegelman: Dana-Farber Cancer Institute, Harvard Medical School

Nature, 2014, vol. 513, issue 7516, 100-104

Abstract: Many patients with cancer experience cachexia, a wasting disorder of adipose tissue and skeletal muscle that leads to weight loss and frailty; now, tumour-derived parathyroid-hormone-related protein has been shown to stimulate the expression of genes involved in heat production in adipose tissues and to have an important role in tissue wasting.

Date: 2014
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DOI: 10.1038/nature13528

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