eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

Lise Boussemart, Hélène Malka-Mahieu, Isabelle Girault, Delphine Allard, Oskar Hemmingsson, Gorana Tomasic, Marina Thomas, Christine Basmadjian, Nigel Ribeiro, Frédéric Thuaud, Christina Mateus, Emilie Routier, Nyam Kamsu-Kom, Sandrine Agoussi, Alexander M. Eggermont, Laurent Désaubry, Caroline Robert () and Stéphan Vagner ()
Additional contact information
Lise Boussemart: Inserm UMR981, Villejuif F-94805, France
Hélène Malka-Mahieu: Inserm UMR981, Villejuif F-94805, France
Isabelle Girault: Inserm UMR981, Villejuif F-94805, France
Delphine Allard: Inserm UMR981, Villejuif F-94805, France
Oskar Hemmingsson: Inserm UMR981, Villejuif F-94805, France
Gorana Tomasic: Gustave Roussy, Villejuif F-94805, France
Marina Thomas: Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France
Christine Basmadjian: CNRS-Strasbourg University, UMR7200, Illkirch F-67400, France
Nigel Ribeiro: CNRS-Strasbourg University, UMR7200, Illkirch F-67400, France
Frédéric Thuaud: CNRS-Strasbourg University, UMR7200, Illkirch F-67400, France
Christina Mateus: Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France
Emilie Routier: Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France
Nyam Kamsu-Kom: Inserm UMR981, Villejuif F-94805, France
Sandrine Agoussi: Inserm UMR981, Villejuif F-94805, France
Alexander M. Eggermont: Université Paris-Sud XI, Kremlin-Bicêtre F-94276, France
Laurent Désaubry: CNRS-Strasbourg University, UMR7200, Illkirch F-67400, France
Caroline Robert: Inserm UMR981, Villejuif F-94805, France
Stéphan Vagner: Inserm UMR981, Villejuif F-94805, France

Nature, 2014, vol. 513, issue 7516, 105-109

Abstract: BRAF mutations occur frequently in melanomas, but patients generally develop resistance to agents targeting mutant BRAF; now, the persistent formation of the translation initiation complex eIF4F has been described as an indicator of multiple mechanisms of resistance that arise in BRAF-mutated tumours and as a promising therapeutic target.

Date: 2014
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DOI: 10.1038/nature13572

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