RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi Takahashi, Lars Vereecke, Mathieu J. M. Bertrand, Linde Duprez, Scott B. Berger, Tatyana Divert, Amanda Gonçalves, Mozes Sze, Barbara Gilbert, Stephanie Kourula, Vera Goossens, Sylvie Lefebvre, Claudia Günther, Christoph Becker, John Bertin, Peter J. Gough, Wim Declercq, Geert van Loo and Peter Vandenabeele ()
Additional contact information
Nozomi Takahashi: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Lars Vereecke: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Mathieu J. M. Bertrand: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Linde Duprez: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Scott B. Berger: Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline
Tatyana Divert: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Amanda Gonçalves: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Mozes Sze: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Barbara Gilbert: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Stephanie Kourula: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Vera Goossens: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Sylvie Lefebvre: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Claudia Günther: Friedrich-Alexander-University, D-91054 Erlangen, Germany
Christoph Becker: Friedrich-Alexander-University, D-91054 Erlangen, Germany
John Bertin: Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline
Peter J. Gough: Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline
Wim Declercq: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Geert van Loo: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
Peter Vandenabeele: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium

Nature, 2014, vol. 513, issue 7516, 95-99

Abstract: This study provides evidence for a critical role of RIPK1 in suppressing caspase-8-mediated cell death and maintaining intestinal homeostasis independently of its kinase activity.

Date: 2014
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DOI: 10.1038/nature13706

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