Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Hao Xu, Jieling Yang, Wenqing Gao, Lin Li, Peng Li, Li Zhang, Yi-Nan Gong, Xiaolan Peng, Jianzhong Jeff Xi, She Chen, Fengchao Wang and Feng Shao ()
Additional contact information
Hao Xu: National Institute of Biological Sciences
Jieling Yang: National Institute of Biological Sciences
Wenqing Gao: National Institute of Biological Sciences
Lin Li: National Institute of Biological Sciences
Peng Li: National Institute of Biological Sciences
Li Zhang: National Institute of Biological Sciences
Yi-Nan Gong: National Institute of Biological Sciences
Xiaolan Peng: National Institute of Biological Sciences
Jianzhong Jeff Xi: College of Engineering, Peking University
She Chen: National Institute of Biological Sciences
Fengchao Wang: National Institute of Biological Sciences
Feng Shao: National Institute of Biological Sciences

Nature, 2014, vol. 513, issue 7517, 237-241

Abstract: The Pyrin inflammasome detects the presence of a pathogen not through recognition of a microbial molecule but by the activity of a bacterial toxin that modifies host Rho activity.

Date: 2014
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DOI: 10.1038/nature13449

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