Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins

Hani Goodarzi, Steven Zhang, Colin G. Buss, Lisa Fish, Saeed Tavazoie () and Sohail F. Tavazoie ()
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Hani Goodarzi: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Steven Zhang: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Colin G. Buss: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Lisa Fish: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Saeed Tavazoie: Columbia University
Sohail F. Tavazoie: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

Nature, 2014, vol. 513, issue 7517, 256-260

Abstract: Linear sequence elements within messenger RNAs are known to be targeted by regulatory factors such as microRNAs for degradation, a process that has been implicated in disease; now, non-linear regulatory structural elements within mRNAs are shown also to be targeted, with the resulting mRNA destabilization mediating breast cancer metastasis.

Date: 2014
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DOI: 10.1038/nature13466

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