Fructose-1,6-bisphosphatase opposes renal carcinoma progression

Bo Li, Bo Qiu, David S. M. Lee, Zandra E. Walton, Joshua D. Ochocki, Lijoy K. Mathew, Anthony Mancuso, Terence P. F. Gade, Brian Keith, Itzhak Nissim and M. Celeste Simon ()
Additional contact information
Bo Li: Abramson Family Cancer Research Institute, University of Pennsylvania
Bo Qiu: Abramson Family Cancer Research Institute, University of Pennsylvania
David S. M. Lee: Abramson Family Cancer Research Institute, University of Pennsylvania
Zandra E. Walton: Abramson Family Cancer Research Institute, University of Pennsylvania
Joshua D. Ochocki: Abramson Family Cancer Research Institute, University of Pennsylvania
Lijoy K. Mathew: Abramson Family Cancer Research Institute, University of Pennsylvania
Anthony Mancuso: Abramson Family Cancer Research Institute, University of Pennsylvania
Terence P. F. Gade: Perelman School of Medicine at the University of Pennsylvania
Brian Keith: Abramson Family Cancer Research Institute, University of Pennsylvania
Itzhak Nissim: Biochemistry and Biophysics, University of Pennsylvania
M. Celeste Simon: Abramson Family Cancer Research Institute, University of Pennsylvania

Nature, 2014, vol. 513, issue 7517, 251-255

Abstract: Fructose-1,6-bisphosphatase is shown to be depleted in clear cell renal cell carcinoma (ccRCC) and inhibits ccRCC progression by antagonizing glycolytic flux in renal tubular epithelial cells and by restraining cell proliferation, glycolysis, and the pentose phosphate pathway in von Hippel–Lindau-protein-deficient ccRCC cells by blocking hypoxia-inducible factor function.

Date: 2014
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DOI: 10.1038/nature13557

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