Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

Qingfeng Zhang (), T. Nicolai Siegel, Rafael M. Martins, Fei Wang, Jun Cao, Qi Gao, Xiu Cheng, Lubin Jiang, Chung-Chau Hon, Christine Scheidig-Benatar, Hiroshi Sakamoto, Louise Turner, Anja T. R. Jensen, Aurelie Claes, Julien Guizetti, Nicholas A. Malmquist and Artur Scherf ()
Additional contact information
Qingfeng Zhang: Research Center for Translational Medicine, Shanghai East Hospital and Institute of Infectious Diseases and Vaccine Development, Tongji University School of Medicine
T. Nicolai Siegel: Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
Rafael M. Martins: Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
Fei Wang: Research Center for Translational Medicine, Shanghai East Hospital and Institute of Infectious Diseases and Vaccine Development, Tongji University School of Medicine
Jun Cao: Jiangsu Institute of Parasitic Diseases, Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), and Jiangsu Provincial Key Laboratory of Parasite Molecular Biology
Qi Gao: Jiangsu Institute of Parasitic Diseases, Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), and Jiangsu Provincial Key Laboratory of Parasite Molecular Biology
Xiu Cheng: Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
Lubin Jiang: Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
Chung-Chau Hon: Cell Biology of Parasitism Unit, Institut Pasteur, and INSERM U786, F-75724 Paris, France
Christine Scheidig-Benatar: Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
Hiroshi Sakamoto: Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
Louise Turner: Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health and Medical Sciences, Copenhagen University Hospital (Rigshospitalet)
Anja T. R. Jensen: Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health and Medical Sciences, Copenhagen University Hospital (Rigshospitalet)
Aurelie Claes: Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
Julien Guizetti: Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
Nicholas A. Malmquist: Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
Artur Scherf: Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France

Nature, 2014, vol. 513, issue 7518, 431-435

Abstract: A novel type of post-transcriptional regulation controls the expression of virulence genes in blood-stage malaria parasites.

Date: 2014
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DOI: 10.1038/nature13468

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