Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

Ofer Fridman, Amir Goldberg, Irine Ronin, Noam Shoresh and Nathalie Q. Balaban ()
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Ofer Fridman: Racah Institute of Physics, The Sudarsky Center for Computational Biology and the Center for NanoScience, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel
Amir Goldberg: Racah Institute of Physics, The Sudarsky Center for Computational Biology and the Center for NanoScience, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel
Irine Ronin: Racah Institute of Physics, The Sudarsky Center for Computational Biology and the Center for NanoScience, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel
Noam Shoresh: Broad Institute of Harvard and MIT
Nathalie Q. Balaban: Racah Institute of Physics, The Sudarsky Center for Computational Biology and the Center for NanoScience, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel

Nature, 2014, vol. 513, issue 7518, 418-421

Abstract: Repeated exposure of the bacterium Escherichia coli to clinically relevant concentrations of ampicillin results in the evolution of tolerance—the ability to survive until the antibiotic concentration diminishes—through an extension of the lag phase, a finding that has implications for slowing the evolution of antibiotic resistance.

Date: 2014
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DOI: 10.1038/nature13469

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