Coordinated regulation of protein synthesis and degradation by mTORC1

Yinan Zhang, Justin Nicholatos, John R. Dreier, Stéphane J. H. Ricoult, Scott B. Widenmaier, Gökhan S. Hotamisligil, David J. Kwiatkowski and Brendan D. Manning ()
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Yinan Zhang: Harvard School of Public Health
Justin Nicholatos: Harvard School of Public Health
John R. Dreier: Brigham and Women’s Hospital, Harvard Medical School
Stéphane J. H. Ricoult: Harvard School of Public Health
Scott B. Widenmaier: Harvard School of Public Health
Gökhan S. Hotamisligil: Harvard School of Public Health
David J. Kwiatkowski: Brigham and Women’s Hospital, Harvard Medical School
Brendan D. Manning: Harvard School of Public Health

Nature, 2014, vol. 513, issue 7518, 440-443

Abstract: mTORC1 is known to stimulate protein synthesis; now, it is shown to also promote the synthesis of proteasomes, which degrade proteins into the amino acids needed to create new proteins.

Date: 2014
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DOI: 10.1038/nature13492

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