GATM gene variants and statin myopathy risk

D. F. Carr, A. Alfirevic (), R. Johnson, H. Chinoy, T. van Staa and M. Pirmohamed
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D. F. Carr: Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK
A. Alfirevic: Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK
R. Johnson: Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK
H. Chinoy: NIHR Manchester Musculoskeletal Biomedical Research Unit, Institute of Inflammation and Repair, University of Manchester, Oxford Road, Manchester M13 9PT, UK
T. van Staa: Health eResearch Centre, Farr Institute for Health Informatics Research, University of Manchester, 1.311 Jean McFarlane Building, Oxford Road, Manchester M13 9PL, UK
M. Pirmohamed: Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK

Nature, 2014, vol. 513, issue 7518, E1-E1

Abstract: Abstract Arising from L. M. Mangravite et al. Nature 502, 377–380 (2013); doi:10.1038/nature12508 Mangravite et al.1 identified six expression quantitative loci (eQTLs) that interacted with simvastatin exposure by using 480 lymphoblastoid cell lines exposed to β-hydroxy simvastatin acid in vitro. One of these SNPs (rs9806699) within the glycine amidinotransferase (GATM) gene was shown to have an association with statin-induced myopathy in two independent cohorts (n = 172 myopathy cases), conferring a protective effect (odds ratio = 0.61, 95% confidence interval = 0.39–0.95, P = 0.03). Our genotyping results from statin myopathy patients do not appear to replicate this finding. There is a Reply to this Brief Communication Arising by Mangravite, L. M. et al. Nature 513, http://dx.doi.org/10.1038/nature13630 (2014).

Date: 2014
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DOI: 10.1038/nature13628

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