Bidirectional switch of the valence associated with a hippocampal contextual memory engram

Roger L. Redondo, Joshua Kim, Autumn L. Arons, Steve Ramirez, Xu Liu and Susumu Tonegawa ()
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Roger L. Redondo: RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Joshua Kim: RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Autumn L. Arons: RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Steve Ramirez: RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Xu Liu: RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Susumu Tonegawa: RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology

Nature, 2014, vol. 513, issue 7518, 426-430

Abstract: An optogenetic approach in mice was used to investigate the neural mechanisms underlying memory valence association; dentate gyrus, but not amygdala, memory engram cells exhibit plasticity in valence associations, suggesting that emotional memory associations can be changed at the circuit level.

Date: 2014
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DOI: 10.1038/nature13725

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