Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio, Ngoc-Quynh Chu, Alison L. Szabo, Thach Chu, Anne Marie Rhebergen, Vikram Jairam, Nika Cyrus, Carolyn E. Brokowski, Stephanie C. Eisenbarth, Gillian M. Phillips, Gary W. Cline, Andrew J. Phillips and Ruslan Medzhitov ()
Additional contact information
Oscar R. Colegio: Yale University School of Medicine
Ngoc-Quynh Chu: Yale University School of Medicine
Alison L. Szabo: Yale University School of Medicine
Thach Chu: Yale University School of Medicine
Anne Marie Rhebergen: Yale University School of Medicine
Vikram Jairam: Yale University School of Medicine
Nika Cyrus: Yale University School of Medicine
Carolyn E. Brokowski: Yale University School of Medicine
Stephanie C. Eisenbarth: Yale University School of Medicine
Gillian M. Phillips: Yale University School of Medicine
Gary W. Cline: Yale University School of Medicine
Andrew J. Phillips: Yale University School of Medicine
Ruslan Medzhitov: Yale University School of Medicine

Nature, 2014, vol. 513, issue 7519, 559-563

Abstract: The growth of tumours is supported by tumour production of lactic acid, which polarizes tumour-associated macrophages to an M2 phenotype through a pathway dependent on hypoxia-inducible factor 1α.

Date: 2014
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DOI: 10.1038/nature13490

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