The alarmin IL-33 promotes regulatory T-cell function in the intestine

Chris Schiering, Thomas Krausgruber, Agnieszka Chomka, Anja Fröhlich, Krista Adelmann, Elizabeth A. Wohlfert, Johanna Pott, Thibault Griseri, Julia Bollrath, Ahmed N. Hegazy, Oliver J. Harrison, Benjamin M. J. Owens, Max Löhning, Yasmine Belkaid, Padraic G. Fallon and Fiona Powrie ()
Additional contact information
Chris Schiering: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Thomas Krausgruber: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Agnieszka Chomka: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Anja Fröhlich: Experimental Immunology, Charité — University Medicine Berlin, and German Rheumatism Research Center (DRFZ), D-10117 Berlin, Germany
Krista Adelmann: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Elizabeth A. Wohlfert: Program in Barrier Immunity and Repair, Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Johanna Pott: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Thibault Griseri: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Julia Bollrath: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Ahmed N. Hegazy: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Oliver J. Harrison: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Benjamin M. J. Owens: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Max Löhning: Experimental Immunology, Charité — University Medicine Berlin, and German Rheumatism Research Center (DRFZ), D-10117 Berlin, Germany
Yasmine Belkaid: Program in Barrier Immunity and Repair, Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Padraic G. Fallon: Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse Street, Dublin 2, Ireland
Fiona Powrie: Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK

Nature, 2014, vol. 513, issue 7519, 564-568

Abstract: The alarmin interleukin-33 is constitutively expressed at barrier sites and released in response to tissue damage; here, the IL-33 receptor ST2 is shown to be preferentially expressed on colonic regulatory T cells, where it promotes regulatory T-cell function and adaptation to the inflammatory tissue environment.

Date: 2014
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DOI: 10.1038/nature13577

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