Joiner et al. reply

Mei-ling A. Joiner (), Olha M. Koval, Jingdong Li, B. Julie He, Chantal Allamargot, Zhan Gao, Elizabeth D. Luczak, Duane D. Hall, Brian D. Fink, Biyi Chen, Jinying Yang, Steven A. Moore, Thomas D. Scholz, Stefan Strack, Peter J. Mohler, William I. Sivitz, Long-Sheng Song and Mark E. Anderson ()
Additional contact information
Mei-ling A. Joiner: Carver College of Medicine, University of Iowa
Olha M. Koval: Carver College of Medicine, University of Iowa
Jingdong Li: Carver College of Medicine, University of Iowa
B. Julie He: Carver College of Medicine, University of Iowa
Chantal Allamargot: University of Iowa Central Microscopy Research Facility, Carver College of Medicine, University of Iowa
Zhan Gao: Carver College of Medicine, University of Iowa
Elizabeth D. Luczak: Carver College of Medicine, University of Iowa
Duane D. Hall: Carver College of Medicine, University of Iowa
Brian D. Fink: Iowa City Veterans Affairs Medical
Biyi Chen: Carver College of Medicine, University of Iowa
Jinying Yang: Carver College of Medicine, University of Iowa
Steven A. Moore: Carver College of Medicine, University of Iowa
Thomas D. Scholz: Carver College of Medicine, University of Iowa
Stefan Strack: Carver College of Medicine, University of Iowa
Peter J. Mohler: Carver College of Medicine, University of Iowa
William I. Sivitz: Carver College of Medicine, University of Iowa
Long-Sheng Song: Carver College of Medicine, University of Iowa
Mark E. Anderson: Carver College of Medicine, University of Iowa

Nature, 2014, vol. 513, issue 7519, E3-E3

Abstract: Abstract Replying to F. Fieni et al. Nature 513, 10.1038/nature13626 (2014) In our Letter1 identifying mitochondrial CaMKII as a crucial component of a Ca2+-dependent process of heart disease, we used multiple methods to show that CaMKII modulates mitochondrial Ca2+ homeostasis, as outlined below. First, we carried out electrophysiology of the mitochondrial calcium uniporter (MCU) current in mitoplasts. In our report1 we did not claim to measure capacitance of the mitoplast separately from the total capacitance of the mitoplast and pipette. Although we concede that the approach of Fieni et al.2 is preferable, we found that even after removing any correction for capacitance, dialysis with constitutively active CaMKII monomers increased MCU current whereas dialysis with catalytically dead CaMKII monomers did not.

Date: 2014
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DOI: 10.1038/nature13627

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