DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

Margarida A. Santos, Robert B. Faryabi, Aysegul V. Ergen, Amanda M. Day, Amy Malhowski, Andres Canela, Masahiro Onozawa, Ji-Eun Lee, Elsa Callen, Paula Gutierrez-Martinez, Hua-Tang Chen, Nancy Wong, Nadia Finkel, Aniruddha Deshpande, Susan Sharrow, Derrick J. Rossi, Keisuke Ito, Kai Ge, Peter D. Aplan, Scott A. Armstrong and André Nussenzweig ()
Additional contact information
Margarida A. Santos: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Robert B. Faryabi: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Aysegul V. Ergen: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Amanda M. Day: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Amy Malhowski: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Andres Canela: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Masahiro Onozawa: The Genetics Branch, National Cancer Institute, National Institutes of Health
Ji-Eun Lee: Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Elsa Callen: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Paula Gutierrez-Martinez: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Hua-Tang Chen: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Nancy Wong: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Nadia Finkel: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health
Aniruddha Deshpande: Memorial Sloan-Kettering Cancer Center
Susan Sharrow: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health
Derrick J. Rossi: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Keisuke Ito: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein Cancer Center, Albert Einstein College of Medicine
Kai Ge: Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Peter D. Aplan: The Genetics Branch, National Cancer Institute, National Institutes of Health
Scott A. Armstrong: Memorial Sloan-Kettering Cancer Center
André Nussenzweig: Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health

Nature, 2014, vol. 514, issue 7520, 107-111

Abstract: Histone methyl-transferase MLL4 is required for stem-cell activity and an aggressive form of acute myeloid leukaemia harbouring the MLL–AF9 oncogene.

Date: 2014
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DOI: 10.1038/nature13483

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