Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

John R. B. Perry (), Felix Day, Cathy E. Elks, Patrick Sulem, Deborah J. Thompson, Teresa Ferreira, Chunyan He, Daniel I. Chasman, Tõnu Esko, Gudmar Thorleifsson, Eva Albrecht, Wei Q. Ang, Tanguy Corre, Diana L. Cousminer, Bjarke Feenstra, Nora Franceschini, Andrea Ganna, Andrew D. Johnson, Sanela Kjellqvist, Kathryn L. Lunetta, George McMahon, Ilja M. Nolte, Lavinia Paternoster, Eleonora Porcu, Albert V. Smith, Lisette Stolk, Alexander Teumer, Natalia Tšernikova, Emmi Tikkanen, Sheila Ulivi, Erin K. Wagner, Najaf Amin, Laura J. Bierut, Enda M. Byrne, Jouke-Jan Hottenga, Daniel L. Koller, Massimo Mangino, Tune H. Pers, Laura M. Yerges-Armstrong, Jing Hua Zhao, Irene L. Andrulis, Hoda Anton-Culver, Femke Atsma, Stefania Bandinelli, Matthias W. Beckmann, Javier Benitez, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Hiltrud Brauch, Hermann Brenner, Julie E. Buring, Jenny Chang-Claude, Stephen Chanock, Jinhui Chen, Georgia Chenevix-Trench, J. Margriet Collée, Fergus J. Couch, David Couper, Andrea D. Coviello, Angela Cox, Kamila Czene, Adamo Pio D’adamo, George Davey Smith, Immaculata De Vivo, Ellen W. Demerath, Joe Dennis, Peter Devilee, Aida K. Dieffenbach, Alison M. Dunning, Gudny Eiriksdottir, Johan G. Eriksson, Peter A. Fasching, Luigi Ferrucci, Dieter Flesch-Janys, Henrik Flyger, Tatiana Foroud, Lude Franke, Melissa E. Garcia, Montserrat García-Closas, Frank Geller, Eco E. J. de Geus, Graham G. Giles, Daniel F. Gudbjartsson, Vilmundur Gudnason, Pascal Guénel, Suiqun Guo, Per Hall, Ute Hamann, Robin Haring, Catharina A. Hartman, Andrew C. Heath, Albert Hofman, Maartje J. Hooning, John L. Hopper, Frank B. Hu, David J. Hunter, David Karasik, Douglas P. Kiel, Julia A. Knight, Veli-Matti Kosma, Zoltan Kutalik, Sandra Lai, Diether Lambrechts, Annika Lindblom, Reedik Mägi, Patrik K. Magnusson, Arto Mannermaa, Nicholas G. Martin, Gisli Masson, Patrick F. McArdle, Wendy L. McArdle, Mads Melbye, Kyriaki Michailidou, Evelin Mihailov, Lili Milani, Roger L. Milne, Heli Nevanlinna, Patrick Neven, Ellen A. Nohr, Albertine J. Oldehinkel, Ben A. Oostra, Aarno Palotie, Munro Peacock, Nancy L. Pedersen, Paolo Peterlongo, Julian Peto, Paul D. P. Pharoah, Dirkje S. Postma, Anneli Pouta, Katri Pylkäs, Paolo Radice, Susan Ring, Fernando Rivadeneira, Antonietta Robino, Lynda M. Rose, Anja Rudolph, Veikko Salomaa, Serena Sanna, David Schlessinger, Marjanka K. Schmidt, Mellissa C. Southey, Ulla Sovio, Meir J. Stampfer, Doris Stöckl, Anna M. Storniolo, Nicholas J. Timpson, Jonathan Tyrer, Jenny A. Visser, Peter Vollenweider, Henry Völzke, Gerard Waeber, Melanie Waldenberger, Henri Wallaschofski, Qin Wang, Gonneke Willemsen, Robert Winqvist, Bruce H. R. Wolffenbuttel, Margaret J. Wright, Dorret I. Boomsma, Michael J. Econs, Kay-Tee Khaw, Ruth J. F. Loos, Mark I. McCarthy, Grant W. Montgomery, John P. Rice, Elizabeth A. Streeten, Unnur Thorsteinsdottir, Cornelia M. van Duijn, Behrooz Z. Alizadeh, Sven Bergmann, Eric Boerwinkle, Heather A. Boyd, Laura Crisponi, Paolo Gasparini, Christian Gieger, Tamara B. Harris, Erik Ingelsson, Marjo-Riitta Järvelin, Peter Kraft, Debbie Lawlor, Andres Metspalu, Craig E. Pennell, Paul M. Ridker, Harold Snieder, Thorkild I. A. Sørensen, Tim D. Spector, David P. Strachan, André G. Uitterlinden, Nicholas J. Wareham, Elisabeth Widen, Marek Zygmunt, Anna Murray, Douglas F. Easton, Kari Stefansson, Joanne M. Murabito () and Ken K. Ong
Additional contact information
John R. B. Perry: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Felix Day: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Cathy E. Elks: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Patrick Sulem: deCODE Genetics, Reykjavik IS-101, Iceland.
Deborah J. Thompson: Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Teresa Ferreira: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Chunyan He: Indiana University Richard M Fairbanks School of Public Health
Daniel I. Chasman: Brigham and Women’s Hospital
Tõnu Esko: Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Gudmar Thorleifsson: deCODE Genetics, Reykjavik IS-101, Iceland.
Eva Albrecht: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Wei Q. Ang: School of Women’s and Infants’ Health, The University of Western Australia, WA-6009, Australia.
Tanguy Corre: University of Lausanne, CH-1005 Lausanne, Switzerland.
Diana L. Cousminer: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland.
Bjarke Feenstra: Statens Serum Institut, DK-2300 Copenhagen, Denmark.
Nora Franceschini: University of North Carolina
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Albert V. Smith: Icelandic Heart Association, IS-201 Kopavogur, Iceland.
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Andres Metspalu: Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Craig E. Pennell: School of Women’s and Infants’ Health, The University of Western Australia, WA-6009, Australia.
Paul M. Ridker: Brigham and Women’s Hospital
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Thorkild I. A. Sørensen: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Denmark.
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Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Elisabeth Widen: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland.
Marek Zygmunt: University Medicine Greifswald, D-17475 Greifswald, Germany.
Anna Murray: University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Douglas F. Easton: Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Kari Stefansson: deCODE Genetics, Reykjavik IS-101, Iceland.
Joanne M. Murabito: NHLBI’s and Boston University’s Framingham Heart Study
Ken K. Ong: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Nature, 2014, vol. 514, issue 7520, 92-97

Abstract: Here 106 genomic loci associated with age at menarche, a marker of puberty timing in females, are identified; these loci show enrichment for genes involved in nuclear hormone receptor function, body mass index, and rare disorders of puberty, and for genes located in imprinted regions, with parent-of-origin specific effects at several loci.

Date: 2014
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