Hemani et al. reply

Gibran Hemani (), Konstantin Shakhbazov, Harm-Jan Westra, Tonu Esko, Anjali K. Henders, Allan F. McRae, Jian Yang, Greg Gibson, Nicholas G. Martin, Andres Metspalu, Lude Franke, Grant W. Montgomery, Peter M. Visscher and Joseph E. Powell
Additional contact information
Gibran Hemani: Queensland Brain Institute, University of Queensland
Konstantin Shakhbazov: Queensland Brain Institute, University of Queensland
Harm-Jan Westra: University Medical Center Groningen, University of Groningen
Tonu Esko: Estonian Genome Center, University of Tartu
Anjali K. Henders: Queensland Institute of Medical Research
Allan F. McRae: Queensland Brain Institute, University of Queensland
Jian Yang: Queensland Brain Institute, University of Queensland
Greg Gibson: School of Biology and Centre for Integrative Genomics, Georgia Institute of Technology
Nicholas G. Martin: Queensland Institute of Medical Research
Andres Metspalu: Estonian Genome Center, University of Tartu
Lude Franke: University Medical Center Groningen, University of Groningen
Grant W. Montgomery: Queensland Institute of Medical Research
Peter M. Visscher: Queensland Brain Institute, University of Queensland
Joseph E. Powell: Queensland Brain Institute, University of Queensland

Nature, 2014, vol. 514, issue 7520, E5-E6

Abstract: Abstract Replying to A. R. Wood et al. Nature 514, 10.1038/nature13691 (2014). We thank Wood et al. 1 for their interesting observations and although their proposed mechanism does not explain all our reported results, we acknowledge that alternative mechanisms could be behind the observation of epistatic signals. Although we replicate our results in large, independent samples, 19/30 of our reported interactions (Table 1 in ref. 2), Wood et al.1 do not replicate in the InCHIANTI data set (n = 450) at a type-I error rate of 0.05/30 = 0.002, including none of our reported cis–trans interactions. Having insufficient data to replicate the discovery interactions makes it problematic to draw firm conclusions on the reported cis–trans effects.

Date: 2014
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DOI: 10.1038/nature13692

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