PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

Thomas De Raedt, Eline Beert, Eric Pasmant, Armelle Luscan, Hilde Brems, Nicolas Ortonne, Kristian Helin, Jason L. Hornick, Victor Mautner, Hildegard Kehrer-Sawatzki, Wade Clapp, James Bradner, Michel Vidaud, Meena Upadhyaya, Eric Legius () and Karen Cichowski ()
Additional contact information
Thomas De Raedt: Brigham and Women’s Hospital
Eline Beert: Catholic University Leuven, 3000 Leuven, Belgium
Eric Pasmant: INSERM UMR_S745 et EA7331, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
Armelle Luscan: INSERM UMR_S745 et EA7331, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
Hilde Brems: Catholic University Leuven, 3000 Leuven, Belgium
Nicolas Ortonne: INSERM UMR_S745 et EA7331, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
Kristian Helin: Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark
Jason L. Hornick: Brigham and Women’s Hospital
Victor Mautner: University Medical Centre, Hamburg-Eppendorf, 20246 Hamburg, Germany
Hildegard Kehrer-Sawatzki: Institute of Human Genetics, University of Ulm, 89081 Ulm, Germany
Wade Clapp: Herman Wells Center for Pediatric Research, Indiana University School of Medicine
James Bradner: Harvard Medical School
Michel Vidaud: INSERM UMR_S745 et EA7331, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
Meena Upadhyaya: Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Eric Legius: Catholic University Leuven, 3000 Leuven, Belgium
Karen Cichowski: Brigham and Women’s Hospital

Nature, 2014, vol. 514, issue 7521, 247-251

Abstract: SUZ12, a component of the PRC2 complex, can also function as a tumour suppressor in certain tumours of the nervous system and melanomas.

Date: 2014
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DOI: 10.1038/nature13561

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