Protein competition switches the function of COP9 from self-renewal to differentiation

Lei Pan, Su Wang, Tinglin Lu, Changjiang Weng, Xiaoqing Song, Joseph K. Park, Jin Sun, Zhi-Hao Yang, Junjing Yu, Hong Tang, Dennis M. McKearin, Daniel A. Chamovitz, Jianquan Ni and Ting Xie ()
Additional contact information
Lei Pan: Stowers Institute for Medical Research, 1000 East 50th Street
Su Wang: Stowers Institute for Medical Research, 1000 East 50th Street
Tinglin Lu: Center for Life Sciences, School of Medicine, Tsinghua University
Changjiang Weng: Stowers Institute for Medical Research, 1000 East 50th Street
Xiaoqing Song: Stowers Institute for Medical Research, 1000 East 50th Street
Joseph K. Park: University of Texas Southwestern Medical Center
Jin Sun: Center for Life Sciences, School of Medicine, Tsinghua University
Zhi-Hao Yang: Center for Life Sciences, School of Medicine, Tsinghua University
Junjing Yu: Stowers Institute for Medical Research, 1000 East 50th Street
Hong Tang: Chinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics, 15 Da Tun Road, Beijing 100101, China
Dennis M. McKearin: University of Texas Southwestern Medical Center
Daniel A. Chamovitz: Tel Aviv University, Tel Aviv 69978, Israel
Jianquan Ni: Center for Life Sciences, School of Medicine, Tsinghua University
Ting Xie: Stowers Institute for Medical Research, 1000 East 50th Street

Nature, 2014, vol. 514, issue 7521, 233-236

Abstract: Using biochemical and genetic approaches, a protein-competition-based mechanism that controls the balance between stem cell self-renewal and differentiation of germline stem cells in the Drosophila melanogaster ovary has been uncovered.

Date: 2014
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DOI: 10.1038/nature13562

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