Noncoding RNA transcription targets AID to divergently transcribed loci in B cells

Evangelos Pefanis, Jiguang Wang, Gerson Rothschild, Junghyun Lim, Jaime Chao, Raul Rabadan (), Aris N. Economides and Uttiya Basu ()
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Evangelos Pefanis: College of Physicians and Surgeons, Columbia University
Jiguang Wang: College of Physicians and Surgeons, Columbia University
Gerson Rothschild: College of Physicians and Surgeons, Columbia University
Junghyun Lim: College of Physicians and Surgeons, Columbia University
Jaime Chao: College of Physicians and Surgeons, Columbia University
Raul Rabadan: College of Physicians and Surgeons, Columbia University
Aris N. Economides: Regeneron Pharmaceuticals
Uttiya Basu: College of Physicians and Surgeons, Columbia University

Nature, 2014, vol. 514, issue 7522, 389-393

Abstract: The 11-subunit RNA exosome is thought to regulate the mammalian noncoding transcriptome; here, a mouse model is generated in which the essential Exosc3 subunit of the RNA exosome in B cells is conditionally deleted, revealing a link between sites of genomic RNA exosome function and AID-mediated chromosomal translocations.

Date: 2014
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DOI: 10.1038/nature13580

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