Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

Delphine Goubau (), Martin Schlee, Safia Deddouche, Andrea J. Pruijssers, Thomas Zillinger, Marion Goldeck, Christine Schuberth, Annemarthe G. Van der Veen, Tsutomu Fujimura, Jan Rehwinkel, Jason A. Iskarpatyoti, Winfried Barchet, Janos Ludwig, Terence S. Dermody, Gunther Hartmann and Caetano Reis e Sousa ()
Additional contact information
Delphine Goubau: Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Martin Schlee: Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany
Safia Deddouche: Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Andrea J. Pruijssers: Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA
Thomas Zillinger: Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany
Marion Goldeck: Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany
Christine Schuberth: Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany
Annemarthe G. Van der Veen: Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Tsutomu Fujimura: Instituto de Biología Funcional y Genómica. Consejo Superior de Investigaciones Científicas/Universidad de Salamanca, Zacarías González 2, 37007, Salamanca, Spain
Jan Rehwinkel: Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Jason A. Iskarpatyoti: Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA
Winfried Barchet: Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany
Janos Ludwig: Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany
Terence S. Dermody: Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA
Gunther Hartmann: Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany
Caetano Reis e Sousa: Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK

Nature, 2014, vol. 514, issue 7522, 372-375

Abstract: The innate immune receptor RIG-I is shown to sense 5′-diphosphate RNAs as found in some viral genomes in addition to its well characterized activation by RNAs bearing 5′-triphosphate moieties.

Date: 2014
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DOI: 10.1038/nature13590

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