Rb suppresses human cone-precursor-derived retinoblastoma tumours

Xiaoliang L. Xu, Hardeep P. Singh, Lu Wang, Dong-Lai Qi, Bradford K. Poulos, David H. Abramson, Suresh C. Jhanwar () and David Cobrinik ()
Additional contact information
Xiaoliang L. Xu: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Hardeep P. Singh: The Vision Center, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
Lu Wang: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Dong-Lai Qi: The Vision Center, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
Bradford K. Poulos: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
David H. Abramson: Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Suresh C. Jhanwar: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
David Cobrinik: The Vision Center, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA

Nature, 2014, vol. 514, issue 7522, 385-388

Abstract: The nature of the retinal cell-type-specific circuitry that predisposes to retinoblastoma is demonstrated, in which a program that is unique to post-mitotic human cone precursors sensitizes to the oncogenic effects of retinoblastoma (Rb) protein depletion; hence, the loss of Rb collaborates with the molecular framework of cone precursors to initiate tumorigenesis.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature13813 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:514:y:2014:i:7522:d:10.1038_nature13813

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13813

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().