High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

Manon D. Schulz, Çiğdem Atay, Jessica Heringer, Franziska K. Romrig, Sarah Schwitalla, Begüm Aydin, Paul K. Ziegler, Julia Varga, Wolfgang Reindl, Claudia Pommerenke, Gabriela Salinas-Riester, Andreas Böck, Carl Alpert, Michael Blaut, Sara C. Polson, Lydia Brandl, Thomas Kirchner, Florian R. Greten, Shawn W. Polson and Melek C. Arkan ()
Additional contact information
Manon D. Schulz: Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
Çiğdem Atay: Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
Jessica Heringer: Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
Franziska K. Romrig: Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
Sarah Schwitalla: Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
Begüm Aydin: Bogazici University, 34342 Bebek, Istanbul, Turkey
Paul K. Ziegler: Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany
Julia Varga: Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany
Wolfgang Reindl: Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany
Claudia Pommerenke: Microarray and Deep-Sequencing Core Facility, University Medical Center Göttingen, 37077 Göttingen, Germany
Gabriela Salinas-Riester: Microarray and Deep-Sequencing Core Facility, University Medical Center Göttingen, 37077 Göttingen, Germany
Andreas Böck: Institute for Mathematical Statistics, Technical University Munich, 81675 Munich, Germany
Carl Alpert: German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
Michael Blaut: German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
Sara C. Polson: Center for Bioinformatics and Computational Biology, Delaware Biotechnology Institute, University of Delaware
Lydia Brandl: Institute of Pathology, Ludwig Maximilians University, 80337 Munich, Germany
Thomas Kirchner: German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Florian R. Greten: Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany
Shawn W. Polson: Center for Bioinformatics and Computational Biology, Delaware Biotechnology Institute, University of Delaware
Melek C. Arkan: Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany

Nature, 2014, vol. 514, issue 7523, 508-512

Abstract: A high-fat diet promotes intestinal tumorigenesis independently of obesity in a mouse model with oncogene activation, by changing the composition of the gut microbiota and altering immune regulation.

Date: 2014
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DOI: 10.1038/nature13398

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