Structure and mechanism of Zn2+-transporting P-type ATPases

Kaituo Wang, Oleg Sitsel, Gabriele Meloni, Henriette Elisabeth Autzen, Magnus Andersson, Tetyana Klymchuk, Anna Marie Nielsen, Douglas C. Rees, Poul Nissen and Pontus Gourdon ()
Additional contact information
Kaituo Wang: Centre for Membrane Pumps in Cells and Disease (PUMPkin), Danish National Research Foundation, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Oleg Sitsel: Centre for Membrane Pumps in Cells and Disease (PUMPkin), Danish National Research Foundation, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Gabriele Meloni: Centre for Membrane Pumps in Cells and Disease (PUMPkin), Danish National Research Foundation, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Henriette Elisabeth Autzen: Centre for Membrane Pumps in Cells and Disease (PUMPkin), Danish National Research Foundation, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Magnus Andersson: Science for Life Laboratory, Swedish e-Science Research Center, KTH Royal Institute of Technology, SE-171 21 Solna, Sweden
Tetyana Klymchuk: Centre for Membrane Pumps in Cells and Disease (PUMPkin), Danish National Research Foundation, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Anna Marie Nielsen: Centre for Membrane Pumps in Cells and Disease (PUMPkin), Danish National Research Foundation, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Douglas C. Rees: California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
Poul Nissen: Centre for Membrane Pumps in Cells and Disease (PUMPkin), Danish National Research Foundation, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Pontus Gourdon: Centre for Membrane Pumps in Cells and Disease (PUMPkin), Danish National Research Foundation, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark

Nature, 2014, vol. 514, issue 7523, 518-522

Abstract: The X-ray crystal structures of a zinc-ion-transporting P-type ATPase are solved in a zinc-free, phosphoenzyme ‘ground’ state and in a transition state of dephosphorylation, characterizing these transporters of an essential micronutrient that is needed for many biological processes but is cytotoxic when free.

Date: 2014
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DOI: 10.1038/nature13618

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