Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

Simona Chera, Delphine Baronnier, Luiza Ghila, Valentina Cigliola, Jan N. Jensen, Guoqiang Gu, Kenichiro Furuyama, Fabrizio Thorel, Fiona M. Gribble, Frank Reimann and Pedro L. Herrera ()
Additional contact information
Simona Chera: Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland
Delphine Baronnier: Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland
Luiza Ghila: Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland
Valentina Cigliola: Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland
Jan N. Jensen: Novo Nordisk A/S, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark
Guoqiang Gu: Cell and Developmental Biology, Vanderbilt University Medical Center, 465 21st Av. South, Nashville, Tennessee 37232, USA
Kenichiro Furuyama: Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland
Fabrizio Thorel: Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland
Fiona M. Gribble: Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, UK
Frank Reimann: Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, UK
Pedro L. Herrera: Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland

Nature, 2014, vol. 514, issue 7523, 503-507

Abstract: An investigation of the influence of age on the generation of insulin-producing cells after β-cell loss in mice reveals that, whereas α-cells can reprogram to produce insulin from puberty to adulthood, efficient reconstitution in the very young is through δ-cell reprogramming, leading to complete diabetes recovery.

Date: 2014
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DOI: 10.1038/nature13633

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