Dendritic cells control fibroblastic reticular network tension and lymph node expansion

Sophie E. Acton (), Aaron J. Farrugia, Jillian L. Astarita, Diego Mourão-Sá, Robert P. Jenkins, Emma Nye, Steven Hooper, Janneke van Blijswijk, Neil C. Rogers, Kathryn J. Snelgrove, Ian Rosewell, Luis F. Moita, Gordon Stamp, Shannon J. Turley, Erik Sahai and Caetano Reis e Sousa ()
Additional contact information
Sophie E. Acton: Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Aaron J. Farrugia: Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Jillian L. Astarita: Dana-Farber Cancer Institute
Diego Mourão-Sá: Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Robert P. Jenkins: Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Emma Nye: Experimental Histopathology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Steven Hooper: Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Janneke van Blijswijk: Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Neil C. Rogers: Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Kathryn J. Snelgrove: Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Ian Rosewell: Transgenics Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK
Luis F. Moita: Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
Gordon Stamp: Experimental Histopathology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Shannon J. Turley: Genentech, One DNA Way, South San Francisco, California 94080, USA
Erik Sahai: Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Caetano Reis e Sousa: Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK

Nature, 2014, vol. 514, issue 7523, 498-502

Abstract: During inflammation, the lymph node stromal compartment is shown to accommodate high numbers of infiltrating lymphocytes by relaxing the cytoskeleton of fibroblastic reticular cells, allowing the latter to stretch and the lymph node to expand.

Date: 2014
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DOI: 10.1038/nature13814

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