Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

Katharine L. Sackton, Nevena Dimova, Xing Zeng, Wei Tian, Mengmeng Zhang, Timothy B. Sackton, Johnathan Meaders, Kathleen L. Pfaff, Frederic Sigoillot, Hongtao Yu, Xuelian Luo and Randall W. King ()
Additional contact information
Katharine L. Sackton: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nevena Dimova: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Xing Zeng: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Wei Tian: University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Mengmeng Zhang: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Timothy B. Sackton: Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA
Johnathan Meaders: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Kathleen L. Pfaff: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Frederic Sigoillot: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Hongtao Yu: University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Xuelian Luo: University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Randall W. King: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2014, vol. 514, issue 7524, 646-649

Abstract: Simultaneous disruption of two different protein–protein interactions within the (APC/C–Cdc20)–substrate complex can synergistically inhibit APC/C-dependent proteolysis and mitotic exit.

Date: 2014
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DOI: 10.1038/nature13660

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