Transcriptional interference by antisense RNA is required for circadian clock function

Zhihong Xue, Qiaohong Ye, Simon R. Anson, Jichen Yang, Guanghua Xiao, David Kowbel, N. Louise Glass, Susan K. Crosthwaite and Yi Liu ()
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Zhihong Xue: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Qiaohong Ye: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Simon R. Anson: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Jichen Yang: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Guanghua Xiao: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
David Kowbel: University of California
N. Louise Glass: University of California
Susan K. Crosthwaite: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Yi Liu: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA

Nature, 2014, vol. 514, issue 7524, 650-653

Abstract: The transcriptions of frq sense and antisense RNAs are mutually inhibitory and form a double negative feedback loop required for robust and sustained circadian rhythmicity: antisense transcription inhibits sense expression by causing chromatin modifications and premature transcription termination.

Date: 2014
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DOI: 10.1038/nature13671

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