Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

Joseph M. Pickard, Corinne F. Maurice, Melissa A. Kinnebrew, Michael C. Abt, Dominik Schenten, Tatyana V. Golovkina, Said R. Bogatyrev, Rustem F. Ismagilov, Eric G. Pamer, Peter J. Turnbaugh and Alexander V. Chervonsky ()
Additional contact information
Joseph M. Pickard: The University of Chicago
Corinne F. Maurice: FAS Center for Systems Biology, Harvard University
Melissa A. Kinnebrew: Memorial Sloan-Kettering Cancer Center
Michael C. Abt: Memorial Sloan-Kettering Cancer Center
Dominik Schenten: The University of Arizona
Tatyana V. Golovkina: The University of Chicago
Said R. Bogatyrev: California Institute of Technology
Rustem F. Ismagilov: California Institute of Technology
Eric G. Pamer: Memorial Sloan-Kettering Cancer Center
Peter J. Turnbaugh: FAS Center for Systems Biology, Harvard University
Alexander V. Chervonsky: The University of Chicago

Nature, 2014, vol. 514, issue 7524, 638-641

Abstract: Systemic exposure to Toll-like receptor (TLR) ligands during sickness is shown to induce fucosylation of the small intestine in mice; some of the fucose is shed into the intestinal lumen, where it provides nourishment for the microbiota.

Date: 2014
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DOI: 10.1038/nature13823

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