Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

Jinghe Huang, Byong H. Kang, Marie Pancera, Jeong Hyun Lee, Tommy Tong, Yu Feng, Hiromi Imamichi, Ivelin S. Georgiev, Gwo-Yu Chuang, Aliaksandr Druz, Nicole A. Doria-Rose, Leo Laub, Kwinten Sliepen, Marit J. van Gils, Alba Torrents de la Peña, Ronald Derking, Per-Johan Klasse, Stephen A. Migueles, Robert T. Bailer, Munir Alam, Pavel Pugach, Barton F. Haynes, Richard T. Wyatt, Rogier W. Sanders, James M. Binley, Andrew B. Ward, John R. Mascola, Peter D. Kwong and Mark Connors ()
Additional contact information
Jinghe Huang: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Byong H. Kang: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Marie Pancera: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Jeong Hyun Lee: The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
Tommy Tong: San Diego Biomedical Research Institute
Yu Feng: International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute
Hiromi Imamichi: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Ivelin S. Georgiev: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Gwo-Yu Chuang: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Aliaksandr Druz: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Nicole A. Doria-Rose: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Leo Laub: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Kwinten Sliepen: Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands
Marit J. van Gils: Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands
Alba Torrents de la Peña: Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands
Ronald Derking: Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands
Per-Johan Klasse: Weill Medical College of Cornell University
Stephen A. Migueles: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Robert T. Bailer: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Munir Alam: Duke Human Vaccine Institute, Duke University
Pavel Pugach: Weill Medical College of Cornell University
Barton F. Haynes: Duke Human Vaccine Institute, Duke University
Richard T. Wyatt: The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
Rogier W. Sanders: Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands
James M. Binley: San Diego Biomedical Research Institute
Andrew B. Ward: The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
John R. Mascola: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Peter D. Kwong: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Mark Connors: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature, 2014, vol. 515, issue 7525, 138-142

Abstract: Molecular and structural characterization is reported for a new broad and potent monoclonal antibody against HIV that binds to an epitope bridging the gp41 and gp120 subunits — the antibody affects a step in virus entry after binding to CD4 and before engagement of CCR5.

Date: 2014
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DOI: 10.1038/nature13601

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