Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer

Diletta Di Mitri, Alberto Toso, Jing Jing Chen, Manuela Sarti, Sandra Pinton, Tanja Rezzonico Jost, Rocco D’Antuono, Erica Montani, Ramon Garcia-Escudero, Ilaria Guccini, Sabela Da Silva-Alvarez, Manuel Collado, Mario Eisenberger, Zhe Zhang, Carlo Catapano, Fabio Grassi and Andrea Alimonti ()
Additional contact information
Diletta Di Mitri: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
Alberto Toso: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
Jing Jing Chen: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
Manuela Sarti: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
Sandra Pinton: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
Tanja Rezzonico Jost: Institute for Research in Biomedicine (IRB)
Rocco D’Antuono: Institute for Research in Biomedicine (IRB)
Erica Montani: Institute for Research in Biomedicine (IRB)
Ramon Garcia-Escudero: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
Ilaria Guccini: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
Sabela Da Silva-Alvarez: Laboratory of Stem Cells in Cancer and Aging, (stemCHUS) Health Research Institute of Santiago de Compostela (IDIS), Clinical University Hospital (CHUS), E15706 Santiago de Compostela, Spain
Manuel Collado: Laboratory of Stem Cells in Cancer and Aging, (stemCHUS) Health Research Institute of Santiago de Compostela (IDIS), Clinical University Hospital (CHUS), E15706 Santiago de Compostela, Spain
Mario Eisenberger: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
Zhe Zhang: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
Carlo Catapano: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
Fabio Grassi: Institute for Research in Biomedicine (IRB)
Andrea Alimonti: Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland

Nature, 2014, vol. 515, issue 7525, 134-137

Abstract: Senescence in cancer can be antagonized by a subset of immune cells acting in a non-cell-autonomous manner.

Date: 2014
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DOI: 10.1038/nature13638

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