Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli

Hongtu Zhao, Gang Sheng, Jiuyu Wang, Min Wang, Gabor Bunkoczi, Weimin Gong, Zhiyi Wei () and Yanli Wang ()
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Hongtu Zhao: Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Gang Sheng: Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Jiuyu Wang: Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Min Wang: Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Gabor Bunkoczi: Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK
Weimin Gong: Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Zhiyi Wei: South University of Science and Technology of China
Yanli Wang: Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences

Nature, 2014, vol. 515, issue 7525, 147-150

Abstract: The CRISPR/Cas system is an RNA-guided bacterial protection system against foreign nucleic acids of bacterial and archaeal origin; here a high-resolution crystal structure of the CRIPSR RNA–Cas complex shows that the CRIPSR RNA plays an essential role not only in target recognition but also in complex assembly.

Date: 2014
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DOI: 10.1038/nature13733

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