Luminal signalling links cell communication to tissue architecture during organogenesis

Sevi Durdu, Murat Iskar, Celine Revenu, Nicole Schieber, Andreas Kunze, Peer Bork, Yannick Schwab and Darren Gilmour ()
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Sevi Durdu: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Murat Iskar: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Celine Revenu: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nicole Schieber: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Andreas Kunze: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Peer Bork: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Yannick Schwab: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Darren Gilmour: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany

Nature, 2014, vol. 515, issue 7525, 120-124

Abstract: Groups of cells within a migrating collective assemble shared luminal cavities that trap and concentrate the signalling molecule fibroblast growth factor, providing a self-organising mechanism to focus and coordinate cell communication within tissues.

Date: 2014
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DOI: 10.1038/nature13852

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