A three-dimensional human neural cell culture model of Alzheimer’s disease

Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Carla D’Avanzo, Hechao Chen, Basavaraj Hooli, Caroline Asselin, Julien Muffat, Justin B. Klee, Can Zhang, Brian J. Wainger, Michael Peitz, Dora M. Kovacs, Clifford J. Woolf, Steven L. Wagner, Rudolph E. Tanzi () and Doo Yeon Kim ()
Additional contact information
Se Hoon Choi: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Young Hye Kim: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Matthias Hebisch: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Christopher Sliwinski: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Seungkyu Lee: FM Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Stem Cell Institute
Carla D’Avanzo: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Hechao Chen: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Basavaraj Hooli: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Caroline Asselin: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Julien Muffat: The Whitehead Institute for Biomedical Research
Justin B. Klee: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Can Zhang: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Brian J. Wainger: FM Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Stem Cell Institute
Michael Peitz: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, 53127 Bonn, Germany
Dora M. Kovacs: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Clifford J. Woolf: FM Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Stem Cell Institute
Steven L. Wagner: University of California, San Diego, La Jolla, California 92093, USA
Rudolph E. Tanzi: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
Doo Yeon Kim: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School

Nature, 2014, vol. 515, issue 7526, 274-278

Abstract: Early-onset familial Alzheimer’s disease mutations induce both amyloid-β and tau pathologies in differentiated human neural stem cells in 3D cultures.

Date: 2014
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DOI: 10.1038/nature13800

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