Structures of bacterial homologues of SWEET transporters in two distinct conformations

Yan Xu, Yuyong Tao, Lily S. Cheung, Chao Fan, Li-Qing Chen, Sophia Xu, Kay Perry, Wolf B. Frommer and Liang Feng ()
Additional contact information
Yan Xu: 279 Campus Drive, Stanford University School of Medicine
Yuyong Tao: 279 Campus Drive, Stanford University School of Medicine
Lily S. Cheung: Carnegie Institution for Science, 260 Panama Street, Stanford, California 94305, USA
Chao Fan: 279 Campus Drive, Stanford University School of Medicine
Li-Qing Chen: Carnegie Institution for Science, 260 Panama Street, Stanford, California 94305, USA
Sophia Xu: Stanford University
Kay Perry: Cornell University, Building 436E, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, USA
Wolf B. Frommer: Carnegie Institution for Science, 260 Panama Street, Stanford, California 94305, USA
Liang Feng: 279 Campus Drive, Stanford University School of Medicine

Nature, 2014, vol. 515, issue 7527, 448-452

Abstract: The X-ray crystal structures of two bacterial homologues of the SWEET sugar transporters are solved in two conformational states, and comparison of these states suggests that transport occurs via a ‘rocker-switch’ mechanism.

Date: 2014
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DOI: 10.1038/nature13670

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