Transcript-RNA-templated DNA recombination and repair

Havva Keskin, Ying Shen, Fei Huang, Mikir Patel, Taehwan Yang, Katie Ashley, Alexander V. Mazin and Francesca Storici ()
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Havva Keskin: School of Biology, Georgia Institute of Technology
Ying Shen: School of Biology, Georgia Institute of Technology
Fei Huang: Drexel University College of Medicine
Mikir Patel: Drexel University College of Medicine
Taehwan Yang: School of Biology, Georgia Institute of Technology
Katie Ashley: School of Biology, Georgia Institute of Technology
Alexander V. Mazin: Drexel University College of Medicine
Francesca Storici: School of Biology, Georgia Institute of Technology

Nature, 2014, vol. 515, issue 7527, 436-439

Abstract: Endogenous RNA transcripts are shown to mediate recombination with yeast chromosomal DNA; as the level of RNAs in the nucleus is quite high, these results may open up new understanding of the plasticity of repair and genome instability mechanisms.

Date: 2014
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DOI: 10.1038/nature13682

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