Discovery and characterization of small molecules that target the GTPase Ral

Chao Yan, Degang Liu, Liwei Li, Michael F. Wempe, Sunny Guin, May Khanna, Jeremy Meier, Brenton Hoffman, Charles Owens, Christina L. Wysoczynski, Matthew D. Nitz, William E. Knabe, Mansoor Ahmed, David L. Brautigan, Bryce M. Paschal, Martin A. Schwartz, David N. M. Jones, David Ross, Samy O. Meroueh and Dan Theodorescu ()
Additional contact information
Chao Yan: University of Colorado
Degang Liu: Indiana University School of Medicine
Liwei Li: Indiana University School of Medicine
Michael F. Wempe: University of Colorado
Sunny Guin: University of Colorado
May Khanna: Indiana University School of Medicine
Jeremy Meier: Cardiovascular Research Center, University of Virginia
Brenton Hoffman: Cardiovascular Research Center, University of Virginia
Charles Owens: University of Colorado
Christina L. Wysoczynski: University of Colorado
Matthew D. Nitz: Immunology, and Cancer Biology, University of Virginia
William E. Knabe: Indiana University School of Medicine
Mansoor Ahmed: Yale University
David L. Brautigan: Immunology, and Cancer Biology, University of Virginia
Bryce M. Paschal: University of Virginia
Martin A. Schwartz: Yale University
David N. M. Jones: University of Colorado
David Ross: University of Colorado
Samy O. Meroueh: Indiana University School of Medicine
Dan Theodorescu: University of Colorado

Nature, 2014, vol. 515, issue 7527, 443-447

Abstract: Using a structure-based approach, small molecule inhibitors that selectively target the GTPase Ral are identified and characterized; these first-generation inhibitors will be valuable tools for elucidating the Ral signalling pathway and constitute a step towards developing Ral-specific agents for cancer therapy.

Date: 2014
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DOI: 10.1038/nature13713

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