Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

Katherine E. Wright, Kathryn A. Hjerrild, Jonathan Bartlett, Alexander D. Douglas, Jing Jin, Rebecca E. Brown, Joseph J. Illingworth, Rebecca Ashfield, Stine B. Clemmensen, Willem A. de Jongh, Simon J. Draper () and Matthew K. Higgins ()
Additional contact information
Katherine E. Wright: University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Kathryn A. Hjerrild: Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Jonathan Bartlett: University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Alexander D. Douglas: Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Jing Jin: Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Rebecca E. Brown: Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Joseph J. Illingworth: Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Rebecca Ashfield: Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Stine B. Clemmensen: ExpreS2ion Biotechnologies, SCION-DTU Science Park, Agern Allé 1, DK-2970 Horsholm, Denmark
Willem A. de Jongh: ExpreS2ion Biotechnologies, SCION-DTU Science Park, Agern Allé 1, DK-2970 Horsholm, Denmark
Simon J. Draper: Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Matthew K. Higgins: University of Oxford, South Parks Road, Oxford OX1 3QU, UK

Nature, 2014, vol. 515, issue 7527, 427-430

Abstract: Reticulocyte-binding protein homologue 5 (PfRH5) of Plasmodium falciparum, the malaria parasite, is known to be necessary for red blood cell invasion, making PfRH5 a promising vaccine candidate; here the X-ray crystallographic structure of PfRH5 in complex with basigin and with inhibitory antibodies is determined.

Date: 2014
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DOI: 10.1038/nature13715

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