Synaptic dysregulation in a human iPS cell model of mental disorders

Zhexing Wen, Ha Nam Nguyen, Ziyuan Guo, Matthew A. Lalli, Xinyuan Wang, Yijing Su, Nam-Shik Kim, Ki-Jun Yoon, Jaehoon Shin, Ce Zhang, Georgia Makri, David Nauen, Huimei Yu, Elmer Guzman, Cheng-Hsuan Chiang, Nadine Yoritomo, Kozo Kaibuchi, Jizhong Zou, Kimberly M. Christian, Linzhao Cheng, Christopher A. Ross, Russell L. Margolis, Gong Chen, Kenneth S. Kosik, Hongjun Song and Guo-li Ming ()
Additional contact information
Zhexing Wen: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Ha Nam Nguyen: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Ziyuan Guo: Huck Institutes of Life Sciences, The Pennsylvania State University, University Park
Matthew A. Lalli: Neuroscience Research Institute, Biomolecular Science and Engineering Program, University of California
Xinyuan Wang: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Yijing Su: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Nam-Shik Kim: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Ki-Jun Yoon: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Jaehoon Shin: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Ce Zhang: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Georgia Makri: Institute for Cell Engineering, Johns Hopkins University School of Medicine
David Nauen: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Huimei Yu: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Elmer Guzman: Neuroscience Research Institute, Biomolecular Science and Engineering Program, University of California
Cheng-Hsuan Chiang: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Nadine Yoritomo: Johns Hopkins University School of Medicine
Kozo Kaibuchi: Nagoya University Graduate School of Medicine, Showa, Nagoya 466-8550, Japan
Jizhong Zou: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Kimberly M. Christian: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Linzhao Cheng: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Christopher A. Ross: Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine
Russell L. Margolis: Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine
Gong Chen: Huck Institutes of Life Sciences, The Pennsylvania State University, University Park
Kenneth S. Kosik: Neuroscience Research Institute, Biomolecular Science and Engineering Program, University of California
Hongjun Song: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Guo-li Ming: Institute for Cell Engineering, Johns Hopkins University School of Medicine

Nature, 2014, vol. 515, issue 7527, 414-418

Abstract: Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology of mental disorders; this approach was used with samples from a family with a schizophrenia pedigree and a DISC1 mutation, revealing synaptic abnormalities and large-scale transcriptional dysregulation.

Date: 2014
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DOI: 10.1038/nature13716

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