Overcoming the limitations of directed C–H functionalizations of heterocycles

Yue-Jin Liu, Hui Xu, Wei-Jun Kong, Ming Shang, Hui-Xiong Dai () and Jin-Quan Yu ()
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Yue-Jin Liu: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Hui Xu: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Wei-Jun Kong: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Ming Shang: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Hui-Xiong Dai: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Jin-Quan Yu: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

Nature, 2014, vol. 515, issue 7527, 389-393

Abstract: A robust and synthetically useful method is reported that overcomes the complications associated with performing C–H functionalization reactions on heterocycles; a reactive PdX2 (X = ArCONOMe) species is generated in situ, and is directed to the appropriate C–H bond by an N-methoxy amide group.

Date: 2014
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DOI: 10.1038/nature13885

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