Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y. Sundier, Ellen L. Robb, Angela Logan, Sergiy M. Nadtochiy, Emily N. J. Ord, Anthony C. Smith, Filmon Eyassu, Rachel Shirley, Chou-Hui Hu, Anna J. Dare, Andrew M. James, Sebastian Rogatti, Richard C. Hartley, Simon Eaton, Ana S. H. Costa, Paul S. Brookes, Sean M. Davidson, Michael R. Duchen, Kourosh Saeb-Parsy, Michael J. Shattock, Alan J. Robinson, Lorraine M. Work, Christian Frezza (), Thomas Krieg () and Michael P. Murphy ()
Additional contact information
Edward T. Chouchani: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Victoria R. Pell: University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Edoardo Gaude: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK
Dunja Aksentijević: King’s College London, British Heart Foundation Centre of Research Excellence, The Rayne Institute, St Thomas’ Hospital, London SE1 7EH, UK
Stephanie Y. Sundier: University College London, Gower Street, London WC1E 6BT, UK
Ellen L. Robb: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Angela Logan: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Sergiy M. Nadtochiy: University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Emily N. J. Ord: Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
Anthony C. Smith: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Filmon Eyassu: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Rachel Shirley: Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
Chou-Hui Hu: University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Anna J. Dare: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Andrew M. James: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Sebastian Rogatti: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Richard C. Hartley: School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK
Simon Eaton: Unit of Paediatric Surgery, UCL Institute of Child Health, London WC1N 1EH, UK
Ana S. H. Costa: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK
Paul S. Brookes: University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Sean M. Davidson: Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, UK
Michael R. Duchen: University College London, Gower Street, London WC1E 6BT, UK
Kourosh Saeb-Parsy: Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK
Michael J. Shattock: King’s College London, British Heart Foundation Centre of Research Excellence, The Rayne Institute, St Thomas’ Hospital, London SE1 7EH, UK
Alan J. Robinson: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
Lorraine M. Work: Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
Christian Frezza: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK
Thomas Krieg: University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Michael P. Murphy: MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK

Nature, 2014, vol. 515, issue 7527, 431-435

Abstract: A metabolomics study on the ischaemic heart identifies succinate as a metabolite that drives the production of reactive oxygen species and contributes to ischaemia-reperfusion injury; pharmacological inhibition of succinate accumulation ameliorates ischaemia-reperfusion injury in a mouse model of heart attack and a rat model of stroke.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (13)

Downloads: (external link)
https://www.nature.com/articles/nature13909 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:515:y:2014:i:7527:d:10.1038_nature13909

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13909

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().