Topologically associating domains are stable units of replication-timing regulation

Benjamin D. Pope, Tyrone Ryba, Vishnu Dileep, Feng Yue, Weisheng Wu, Olgert Denas, Daniel L. Vera, Yanli Wang, R. Scott Hansen, Theresa K. Canfield, Robert E. Thurman, Yong Cheng, Günhan Gülsoy, Jonathan H. Dennis, Michael P. Snyder, John A. Stamatoyannopoulos, James Taylor, Ross C. Hardison, Tamer Kahveci, Bing Ren and David M. Gilbert ()
Additional contact information
Benjamin D. Pope: 319 Stadium Drive, Florida State University
Tyrone Ryba: 5800 Bay Shore Road, New College of Florida
Vishnu Dileep: 319 Stadium Drive, Florida State University
Feng Yue: School of Medicine, The Pennsylvania State University
Weisheng Wu: Center for Comparative Genomics and Bioinformatics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park
Olgert Denas: Emory University, O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta, Georgia 30322, USA
Daniel L. Vera: 319 Stadium Drive, Florida State University
Yanli Wang: Bioinformatics and Genomics Program, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park
R. Scott Hansen: University of Washington
Theresa K. Canfield: University of Washington
Robert E. Thurman: University of Washington
Yong Cheng: Stanford University, 300 Pasteur Drive, MC-5477 Stanford, California 94305, USA
Günhan Gülsoy: Computer and Information Sciences and Engineering, University of Florida
Jonathan H. Dennis: 319 Stadium Drive, Florida State University
Michael P. Snyder: Stanford University, 300 Pasteur Drive, MC-5477 Stanford, California 94305, USA
John A. Stamatoyannopoulos: University of Washington
James Taylor: Emory University, O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta, Georgia 30322, USA
Ross C. Hardison: Center for Comparative Genomics and Bioinformatics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park
Tamer Kahveci: Computer and Information Sciences and Engineering, University of Florida
Bing Ren: Ludwig Institute for Cancer Research and University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA
David M. Gilbert: 319 Stadium Drive, Florida State University

Nature, 2014, vol. 515, issue 7527, 402-405

Abstract: A study of DNA replication timing in mouse and human cells reveals that replication domains (domains of the genome which replicate at the same time) share a correlation with topologically associating domains; these results reconcile cell-type-specific sub-nuclear compartmentalization with developmentally stable chromosome domains and offer a unified model for large scale chromosome structure and function.

Date: 2014
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DOI: 10.1038/nature13986

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