Tolerance lies in the timing

Nicholas R. J. Gascoigne ()
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Nicholas R. J. Gascoigne: Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore.

Nature, 2014, vol. 515, issue 7528, 502-503

Abstract: During immune-cell development, potentially self-reactive T cells are eliminated. It emerges that recruitment of a co-receptor bound to the T-cell receptor by the enzyme Lck is the rate-limiting step in this negative selection.

Date: 2014
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DOI: 10.1038/515502a

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